Nickolas Papadopoulos, Ph.D.

Professor of Oncology and Pathology at the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University

Dr. Nickolas Papadopoulos is an expert in cancer diagnostics and the development of diagnostic tests. He is internationally known as a co‐discoverer of the genetic basis of the predisposition to hereditary nonpolyposis colon cancer (HNPCC).


Nick holds a Ph.D. from the University of Texas Health Science Center at Houston and a B.S. from Aristotelion University of Thessaloniki.

His discovery that mutations in the mismatch repair genes predispose to HNPCC had important ramifications for the understanding of cancers with a very high rate of mutations and led to the development of diagnostic tests for the presymptomatic diagnosis of individuals with HNPCC. Nick part of the interdisciplinary team that was first to sequence all of the protein coding genes and determine genetic alterations and construct expression profiles in multiple tumors of four different common human cancers. Later, he identified novel mutations in chromatin remodeling genes, connecting genetic alterations to epigenetic changes. Currently, Nick is focused on translating the genetic information derived from cancer genome analyses to clinical applications in early detection, diagnosis and monitoring of cancer.

Nick is currently professor of oncology and pathology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University School of Medicine.

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